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Phosducin Photoreceptor signal transduction
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PhosducinDr. Craft and Dr. Zhu have discovered significant new protein partners for phosducin isoforms: SUG1 is involved in proteosomal degradation and CRX is a cone rod homeobox transcription factor (http://www.molvis.org/molvis/v4/p13/, and Mol. Cell Biol., 2000). Phosducin, normally found in the cytoplasm, regulates Gbg binding proteins; however, phosducin also can enter the nucleus and inhibit the transcriptional activity of CRX, the major developmental regulator that determines the cone and rod photoreceptor lineage. |
